American Journal of Obstetrics and Gynecology
ResearchOncologyProspective validation of a laparoscopic predictive model for optimal cytoreduction in advanced ovarian carcinoma
Section snippets
Materials and Methods
Between December 2004 and March 2007, 150 patients, presenting with suspicious ovarian/peritoneal cancer at the Division of Gynecologic Oncology of the Catholic University of Rome and Campobasso, were considered eligible for the protocol. However, only patients with a clinical and/or radiological diagnosis of advanced (FIGO stages III-IV) ovarian/peritoneal cancer were consecutively enrolled in the study. Moreover, the trial included cases to submit to interval debulking surgery with suboptimal
Results
In the study period, 113 consecutive patients were enrolled at the Division of Gynecologic Oncology of the Catholic University of Rome and Campobasso.
Among them, 91 (80.5%) were submitted to primary surgery for suspected advanced ovarian carcinoma; the remaining 22 cases (19.5%) were represented by diagnosed primarily unresectable ovarian cancer triaged to interval debulking surgery after neoadjuvant platinum/paclitaxel based chemotherapy. The median age was 59 years (range, 34-81); 41 patients
Comment
This study confirms the use of a statistical model based on laparoscopically assessed parameters to predict the chances of achieving optimal cytoreduction in a large prospective series of advanced ovarian cancer patients. Although it could be observed that the procedure negatively influences the aggressiveness of primary cytoreduction, 50% of optimal debulking obtained well compares with data reported in the literature. Moreover, when debulking surgery was divided according to the
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Cite this article as: Fagotti A, Ferrandina G, Fanfani F, et al. Prospective validation of a laparoscopic predictive model for optimal cytoreduction in advanced ovarian carcinoma. Am J Obstet Gynecol 2008;199:642.e1-642.e6.