Transactions from the Annual Meeting of the American Gynecological and Obstetrical SocietyThe role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer
Section snippets
Risk assessment
The Yale University, Northwestern University, and New York University ovarian cancer early detection programs began in 1990, 1996, and 1999, respectively; in 1999 they became incorporated into the National Cancer Institute's Early Detection Research Network as the National Ovarian Cancer Early Detection Program (NOCEDP). All institutions use institutional review board–approved protocols, and all participants provided written consent. Only asymptomatic women who were deemed to be at higher risk
Results
A total of 12,709 scans have been performed on 4526 women (premenopausal, 2610; postmenopausal, 1916) since 1990. Visualization of both ovaries was noted in 98% of premenopausal women and 94% of menopausal women. Recall rates at less than the routine 6-month interval were 0.4% in the premenopausal group and 0.3 % in menopausal women. Cystic masses >2.5 cm. were visualized in 12.6% of premenopausal women and 6.4% of menopausal women. A total of 98 persistent adnexal masses were identified, and
Comment
The NOCEDP as part of the National Cancer Institute's Early Detection Research Network is committed to the development of effective means for the accurate detection of early-stage EOC. Within the NOCEDP the identification of clinically relevant serum/plasma markers that are based on ovarian carcinogenesis, invasion, and metastasis are combined with newly developed diagnostic technologies to achieve this goal. Despite the significant advances in diagnostic sonography, we report its present
Acknowledgments
We thank the late Dr Kenneth Taylor for his participation, support, and guidance in the development of the NOCEDP and in the preparation of this manuscript.
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Cited by (0)
Supported by National Cancer Institute grant UO1CA85133; Early Detection Research Network; National Cancer Institute grant P50 CA83639; National Institutes of Health grants R01 CA89503, RO1 CA82562, and RO1 CA01015; Friends of Prentice Foundation; Northwestern Memorial Hospital; Stenn Fund for Ovarian Cancer Research; Joanne Silverman Cancer Foundation; Kaleidoscope of Hope Foundation; Illinois Department of Public Health; Lynne Cohen Foundation; Chicago Bears Care; Lynne Sage Foundation; the Robert H. Lurie Comprehensive Cancer Center, and the New York University Cancer Institute.
Presented at the 23rd Annual Meeting of the American Gynecological and Obstetrical Society, September 9-11, 2004, Bolton Landing, NY.