Original articleOptical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration
Section snippets
Methods
This prospective interventional case series adhered to the tenets of the Declaration of Helsinki and was approved by the UCLA Institutional Review Board, which allowed recruitment of patients, review of clinical charts, and the acquisition of OCT angiography scans with the RTVue XR Avanti with AngioVue. The study was carried out in accordance with HIPAA regulations. Patients diagnosed with AMD and RPE detachment associated with active or chronic type 1 neovascularization as identified with
Results
Thirty-three eyes of 25 patients were included in the study (Table 1). The mean age at the baseline visit was 79 years (range, 64–97 years), and 14 patients (56%) were female. Snellen visual acuity at the baseline visit ranged from 20/25 to counting fingers at 1 foot with a median of 20/40. The most commonly administered treatment regimen was a combination of aflibercept and ranibizumab in 13 eyes (39%), whereas the remainder received a monotherapy of either aflibercept (n = 8; 24%),
Discussion
OCT angiography provides a unique opportunity to directly visualize and study occult neovascular membranes in AMD such as type 1 complexes, which are located under the RPE, and the microvascular details of which are not easily identified with conventional angiography. While OCT angiography cannot identify pathologic vessels in all patients, we were able to collect 33 eyes with AMD and RPE detachment associated with type 1 neovascularization, and to carefully study, characterize, and analyze the
Dr Laura Kuehlewein is a clinical research fellow at the Institute for Ophthalmic Research at the Centre for Ophthalmology and Werner Reichardt Centre for Integrative Neuroscience at Eberhard Karls University, Tuebingen, Germany. She completed a clinical research fellowship at Doheny Eye Institute and the Department of Ophthalmology at David Geffen School of Medicine at UCLA, Los Angeles, California in 2014/ 2015.
References (27)
Visual acuity measurements
J Cataract Refract Surg
(2004)- et al.
Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration
Ophthalmology
(2014) - et al.
Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
Mol Aspects Med
(2012) Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration
Am J Ophthalmol
(2009)- et al.
Retinal pigment epithelial cell loss assessed by fundus autofluorescence imaging in neovascular age-related macular degeneration
Ophthalmology
(2013) - et al.
Choroidal neovascularization
Am J Ophthalmol
(2004) - et al.
Anti-angiogenesis in cancer therapy: Hercules and hydra
Cancer Lett
(2013) - et al.
Do we need a new classification for choroidal neovascularization in age-related macular degeneration?
Retina
(2010) - et al.
The incidence of neovascular subtypes in newly diagnosed neovascular age-related macular degeneration
Am J Ophthalmol
(2014) - et al.
Optical coherence angiography
Opt Express
(2006)
Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Opt Express
Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography
JAMA Ophthalmol
Ultrahigh-speed swept-source OCT angiography in exudative AMD
Ophthalmic Surg Lasers Imaging Retina
Cited by (284)
Polypoidal Choroidal Vasculopathy: Evaluation Based on 3-Dimensional Reconstruction of OCT Angiography
2024, Ophthalmology RetinaTowards a better understanding of non-exudative choroidal and macular neovascularization
2023, Progress in Retinal and Eye ResearchOCT angiography biomarkers in type 1 choroidal neovascularisation after one year of aflibercept treatment
2022, Archivos de la Sociedad Espanola de OftalmologiaExpert consensus on imaging model and application of advancing age-related macular degeneration (2024)
2024, Chinese Journal of Experimental OphthalmologyOptical Coherence Tomography Angiography: A 2023 Focused Update on Age-Related Macular Degeneration
2024, Ophthalmology and Therapy
Dr Laura Kuehlewein is a clinical research fellow at the Institute for Ophthalmic Research at the Centre for Ophthalmology and Werner Reichardt Centre for Integrative Neuroscience at Eberhard Karls University, Tuebingen, Germany. She completed a clinical research fellowship at Doheny Eye Institute and the Department of Ophthalmology at David Geffen School of Medicine at UCLA, Los Angeles, California in 2014/ 2015.
Dr David Sarraf is Clinical Professor of Ophthalmology at the Stein Eye Institute at UCLA. He is co-director of the Pacific Retina Club and the International Retinal Imaging Symposium and is a member of the ASRS, Retina Society and Gass Club and is an executive board member in the Macula Society. Dr Sarraf was recently nominated to the American Ophthalmological Society because of his research work in macular degeneration.