Original articleLocal Recurrence After Primary Proton Beam Therapy in Uveal Melanoma: Risk Factors, Retreatment Approaches, and Outcome
Section snippets
Methods
The study was approved by the institutional review board of the Charité-Universitätsmedizin Berlin, Berlin, Germany, and was in accordance with the tenets of the Declaration of Helsinki. All patients with initial diagnosis of choroidal or ciliary body melanoma that were treated with primary proton beam therapy at the Ocular Oncology Service at Charité Berlin and the Helmholtz Center Berlin between May 1998 and December 2008 were reviewed for local recurrence. In the framework of our treatment
Results
We included 982 patients, of whom 35 patients (3.6%) developed local recurrence after proton beam therapy. The median follow-up was 60.7 months (6.0–170.4 months). The local tumor control rate was 96.4%. The Kaplan-Meier estimate for local recurrence was 2% (± 1%) at 1 year, 3% (± 1%) at 3 years, 4% (± 1%) at 5 years, and 6% (± 1%) at 10 years. After proton beam therapy, the median time local recurrence occurred was 17.5 months (1.3–88.7 months).
Time of overall survival differed significantly (P
Discussion
Proton beam therapy is a safe treatment option for uveal melanoma, resulting in good local control and eye retention rates. Our local control rate of 96% and 94% at 5 and 10 years, respectively, was very similar to the rate described by Egger and associates (96% and 95%).4 Our local recurrence rate of 4% at 5 years is also similar to rates previously described (2%–8.4% at 5 years).1, 3, 4, 5, 6, 7, 8, 9, 10, 11 The last recurrence in our study was detected 7.5 years after proton beam therapy,
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