Original articleDiagnostic Classification of Retinal Nerve Fiber Layer Measurement in Myopic Eyes: A Comparison Between Time-Domain and Spectral-Domain Optical Coherence Tomography
Section snippets
Subjects
One hundred Chinese myopic subjects were recruited in our study. One eye from each subject was randomly selected. All subjects received complete ophthalmic examinations in Joint Shantou International Eye Center, which included visual acuity, intraocular pressure (IOP) measurement, refraction, axial length measurement by IOL master (Carl Zeiss Meditec), and dilated fundus stereoscopic examination. All the included eyes have spherical equivalent of less than −0.5 diopters (D) and no other
Results
After excluding 2 subjects with unreliable visual field tests and 1 for extensive PPA, 97 eyes from 97 subjects (43 female and 61 right eyes) were analyzed. The mean age, axial length, and spherical equivalent were 22.84 ± 3.92 years (range, 18-40), 25.55 ± 1.11 mm (range, 22.52–28.77 mm), and −4.93 ± 2.17 D (range, −1.00 to −12.75 D), respectively. The visual field mean deviation and pattern standard deviation were −2.13 ± 1.12 dB and 1.49 ± 0.98 dB. The signal strength of Stratus OCT was
Discussion
In this study, we found that nasal RNFL measurement was frequently classified as borderline or outside normal limits in both OCTs and that the frequency of abnormal classification of RNFL measurement was significantly higher in Cirrus HD-OCT than Stratus OCT. Eyes with smaller optic disc size and longer axial length were found to be associated with significantly higher percentages of abnormal diagnostic classification in both devices.
The Stratus OCT is a time-domain OCT that has been shown
Mingzhi Zhang, is a Professor of Glaucoma at Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong. She is experienced in glaucoma surgery and cataract and refractive surgery. Dr Zhang's primary research focus is ocular imaging and neuroprotection in glaucoma.
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Cited by (27)
Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis
2019, The Lancet Digital HealthCitation Excerpt :Furthermore, diagnosis of glaucoma based on thickness of the retinal nerve fibre layer and built-in normative databases might not be reliable, because the layered thickness is affected by various factors including axial length, myopia, age, optic disc size, and signal strength.12–15 For example, eyes with small optic discs and long optic axes are associated with significantly increased percentages of abnormal diagnostic classification based on an SDOCT built-in normative database,16 resulting in false-positive errors. Deep learning with convolutional neural networks has been extensively used in medical imaging—particularly for pattern recognition and image classification.17
Assessment of Optical Coherence Tomography Color Probability Codes in Myopic Glaucoma Eyes After Applying a Myopic Normative Database
2017, American Journal of OphthalmologyDiagnostic classification of macular ganglion cell and retinal nerve fiber layer analysis: Differentiation of false-positives from glaucoma
2015, OphthalmologyCitation Excerpt :Despite the relatively small number of eyes (n = 39) with abnormal GCA deviation maps, we believe that these findings can provide valuable information to clinicians for differentiating between real and false-positive GCIPL abnormalities. The rate and associated factors of abnormal RNFL diagnostic classification have been investigated.6,8–10 Although the criteria of abnormal RNFL maps were different from ours, Yamashita et al8 and Kim et al16 reported that longer axial lengths and smaller disc areas were associated with false-positive RNFL maps, which is in accordance with our results.
Diagnostic capability of peripapillary retinal thickness in glaucoma using 3D volume scans
2015, American Journal of OphthalmologyCitation Excerpt :In summary, compared to RNFL thickness, RT is consistently easier to measure accurately in glaucoma patients, especially in those with moderate to severe glaucoma. Peripapillary RT measurements in glaucoma may have some other possible advantages over RNFL measurements, especially if there are conditions that may decrease the accuracy of RNFL measurements, such as myopia, PPA, and severe glaucoma.15,16,18,21,41 In this study, we specifically looked at PPA, in order to determine if PPA affects the diagnostic capability of RT measurements.
Macular imaging in highly myopic eyes with and without glaucoma
2013, American Journal of Ophthalmology
Mingzhi Zhang, is a Professor of Glaucoma at Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong. She is experienced in glaucoma surgery and cataract and refractive surgery. Dr Zhang's primary research focus is ocular imaging and neuroprotection in glaucoma.
Kunliang Qiu, is currently a resident at Department of Glaucoma, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong. Dr Qiu is interested in ocular imaging with hopes of becoming a proliferative clinician-scientist.