Emergency medicine questions: Can tranexamic acid be used to treat upper gastrointestinal bleeds?

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  • Tranexamic acid for gastrointestinal bleeding: A systematic review with meta-analysis of randomized clinical trials

    2021, American Journal of Emergency Medicine
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    Physicians may administer TXA for trauma patients at the first encounter in the emergency department, and TXA has been widely discussed in the field of emergency medicine over the past decade [10-15]. Although the use of TXA for treating gastrointestinal bleeding is an important clinical topic in emergency medicine [16], no clear relevant recommendations are available. Accordingly, a series of studies have reported the possible effectiveness of TXA in the treatment of acute gastrointestinal bleeding.

  • Endoscopic management of nonvariceal upper gastrointestinal bleeding

    2019, Best Practice and Research: Clinical Gastroenterology
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    It remains uncertain whether this finding can be extrapolated to patients outside Asia. Tranexamic acid is an antifibrinolytic drug that has been used for prevention of different types of bleeding for several decades [60]. Although early trials and metaanalysis suggested that tranexamic acid prevents recurrent bleeding and reduces mortality [61], the quality of these studies were mostly suboptimal.

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