Trial DesignThe Prospective Urban Rural Epidemiology (PURE) study: Examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries
Section snippets
Objectives
The framework of the PURE study is based on the assumption that the ‘causal’ pathways for the development of CVD involve influences at multiple levels. Characteristics of countries (eg, policy and economic environment) influence the characteristics of communities (eg, built environment, nutrition environment, and sociocultural factors), and households (eg, family structure, income, housing). These in turn influence individual lifestyle behaviors (physical activity, diet, psychosocial behavior)
Methods
The PURE study aims to recruit 150,000 adults initially aged 35 to 70 years from communities in low-, middle-, and high-income regions of the world representing various levels of development and encompassing great sociocultural diversity (Figure 2). Recruitment commenced in 2003 and is expected to be complete by March 2009.
The Prospective Urban Rural Epidemiology (PURE) study is an investigator-led study that is funded through a variety of sources including the Canadian Institutes of Health
Conclusions
The PURE study is unique in both its goals and scope. Currently, no similar study exists that addresses questions regarding the cause and development of CVRFs and disease within populations with comparable coverage, particularly of low and middle income countries. The PURE study is being conducted by a study team with experience in conducting international studies, and the data collection instruments have been developed from international epidemiological studies such as the INTERHEART study.
Acknowledgements
Local investigators input in varying amounts to the design and protocol development of this study. However, the authors of this article are solely responsible for the design and conduct of this study, all study analyses included in this article, the drafting and edition of the manuscript and its final contents.
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See Appendix B for a complete listing of The PURE Investigators-Writing group.