Original InvestigationMass and Fat Infiltration of Intercostal Muscles Measured by CT Histogram Analysis and Their Correlations with COPD Severity
Section snippets
Subjects
From December 2010 to April 2012, 98 male subjects were retrospectively recruited from patients with COPD at a single institution. The inclusion criteria were age ≥50 years, clinical diagnosis of COPD, and FEV1/FVC ratio of <0.7. Our study excluded the patients with infectious and interstitial lung diseases that could affect the attenuation and volume of the lung parenchyma. Additional exclusion criteria included fluid overload state (eg, pleural and pericardial effusion, ascites, or anasarca),
Clinical Characteristics and Interobserver Reliability of Respiratory Muscle Measurements
The 98 male patients with COPD were divided into four groups according to GOLD criteria, and the basic clinical and pulmonary function data were provided in Table 1. No significant differences were found in the age and smoking history among the four groups.
Interobserver reliability analysis was performed for intercostal CSAs, intercostal attenuation, latissimus CSAs, and latissimus attenuation, and each value was obtained by two chest radiologists. The kappa coefficients for intercostal CSAs,
Discussion
In the present study, we propose a sophisticated method for quantifying the mass and fat infiltration of intercostal and latissimus dorsi muscles using CT histogram analysis. Our study found that intercostal mass and intercostal attenuation were significantly correlated with COPD severity. Furthermore, emphysema extent was significantly correlated with COPD severity.
Intercostal muscles are relatively small structures with complex geometry; therefore, it was challenging to measure intercostal
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