Spinal muscular atrophy (SMA) is a deleterious neuromuscular disease leading to death in children. Numerous plant extracts exert exemplary neuroprotection against SMA. In this chapter, the efficacy of Brucea javanica, Tripterygium wilfordii, and Kiwi fruit has been explained. In addition, efficacy of nusinersen therapy and RNA-targeted therapy has been focused upon. The nusinersen drug improved motor function and increased the magnitude of muscle action potential of the ulnar and peroneal nerve. Despite the amelioration of SMA symptoms by currently available drugs and plant extracts, there is an impending need to validate current therapeutics and look for novel therapeutic molecules.
