CorrespondenceThe harms of early cessation of trials on systematic reviews
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Cited by (3)
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial
2021, The Lancet Gastroenterology and HepatologyCitation Excerpt :However, one multicentre RCT (LEOPARD-2) was prematurely stopped because of safety concerns, as 90-day mortality was higher in the LPD group than in the OPD group.7 The results of the three RCTs that compared LPD with OPD have been disputed because of their small sample sizes and the potential negative effects of the long LPD learning curve.14–16 A broad consensus exists that LPD should be limited to experienced surgeons at high-volume centres, and that trials should be done only in centres where the LPD learning curve has been completed.17,18
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