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Treating constipation with bile: a new target

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References (12)

  • M Camilleri et al.

    Therapeutic targeting of bile acids

    Am J Physiol Gastrointest Liver Physiol

    (2015)
  • A Acosta et al.

    Elobixibat and its potential role in chronic idiopathic constipation

    Therap Adv Gastroenterol

    (2014)
  • AF Hofmann

    Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last

    Expert Rev Gastroenterol. Hepatol

    (2009)
  • HS Mekhjian et al.

    Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man

    J Clin Invest

    (1971)
  • PA Bampton et al.

    The proximal colonic motor response to rectal mechanical andchemical stimulation

    Am J Physiol Gastrointest Liver Physiol

    (2002)
  • TH Karlsen et al.

    Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis

    Aliment Pharmacol Ther

    (2014)
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Cited by (3)

  • Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways

    2020, Journal of Dairy Science
    Citation Excerpt :

    Some research has reported that unsaturated fatty acids can accelerate the recovery of gut motility (Zhang et al., 2011). Bile acid biosynthesis is the top altered metabolic pathway enriched in serum metabolomics analysis, and a few studies have reported that bile acid metabolism in constipated patients was changed (Abrahamsson et al., 2008; Maneerattanaporn and Chey, 2011; Rao, 2018). Bile acids serve as physiological laxatives and can activate TGR5 expressed by enterochromaffin cells, which further release 5-hydroxytryptamine and calcitonin gene-related protein (Snape et al., 1980; Keely et al., 2007), and bile acids were suggested to improve gut motility via the enteric nervous system (Karlström et al., 1986).

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