Review
Modern research thoughts and methods on bio-active components of TCM formulae

https://doi.org/10.1016/S1875-5364(22)60206-1Get rights and content

Abstract

TCM formulae are the important guidances for clinical application of traditional Chinese medicines, which follow the principles of diagnosis and treatment in TCM. Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines. With the rapid development of modern instruments and technology, many new theories, methods and strategies are emerging, which upgrade the research of TCM formulae into a higher level. Only when the medicinal efficacy, bio-active components, function mechanism of TCM formulae are understood, we can guarantee TCM safety and quality control. In this paper, we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study, serum pharmacology and serum pharmacochemistry, association analysis, biochromatography, network pharmacology, metabolomics and proteomics, so as to provide reference for the research and development of TCM in the future.

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    Available online 20 Jul., 2022

    [Research funding] This work was supported by the Key Research and Development Program of Shaanxi (No. 2019ZDLSF04-05), the National Natural Science Foundation of China (No. 81974522), the Subject Innovation Team of Shaanxi University of Chinese Medicine (No. 2019-YL10) and the Youth Innovation Team of Shaanxi Universities (2020)

    These authors have no conflict of interest to declare.

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