Trends in Neurosciences
ReviewMetabolic effects of nigrostriatal denervation in basal ganglia
Selected references (53)
The functional anatomy of basal ganglia disorders
Trends Neurosci.
(1989)Primate models of movement disorders of basal ganglia origin
Trends Neurosci.
(1990)Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Brain Res.
(1998)Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey
Neuropharmacology
(1985)Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the primate
Life Sci.
(1987)Cerebral metabolism of parkinsonian primates 21 days after MPTP
Exp. Neural.
(1988)Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine
Neuroscience
(1989)Re-evaluation of the functional anatomy of the basal ganglia in normal and parkinsonian states
Neuroscience
(1997)Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus
Neuroscience
(1996)- et al.
Convergence of subthalamic and striatal efferents at pallidal level in primates: an anterograde double-labeling study with biocytin and PHA-L
Brain Res.
(1992)
Intracellular study of rat globus pallidus neurons: membrane properties and responses to neostriatal, subthalamic and nigral stimulation
Brain Res.
Functional anatomy of the basal ganglia. 1. The cortico-basal ganglia-thalamo-cortical loop
Brain Res. Rev.
Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data
Brain Res.
Metabolic activity of excitatory parafascicular and pedunculopontine inputs to the subthalamic nucleus in a rat model of Parkinson's disease
Neuroscience
Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's models rats
Brain Res.
Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls
Neuroscience
Excitatory amino acid binding sites in the basal ganglia of the rat: a quantitative autoradiographic study
Neuroscience
Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches
Trends Pharmacol. Sci.
Pharmacological study of the cortical-induced excitation of subthalamic nucleus neurons in the rat: evidence for amino acids as putative neurotransmitters
Neuroscience
Localization of striatal excitatory amino acid binding site subtypes to striatonigral projection neurons
Brain Res.
MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats
Brain Res.
Functional activity of zona incerta neurons is altered after nigrostriatal denervation in hemiparkinsonian rats
Exp. Neural.
Evidence that projections from substantia innominata to zona incerta and mesencephalic locomotor region contribute to locomotor activity
Brain Res.
AMPA glutamate receptor activation in the posterior zona incerta inhibits amphetamine-and apomorphine-induced stereotypy
Brain Res.
AMPA/kainic acid glutamate receptor antagonism in the zona incerta dorsal to the subthalamic nucleus inhibits amphetamine-induced stereotypy but not locomotor activity
Brain Res.
Activation of AMPA/kainic acid glutamate receptors in the zona incerta stimulates locomotor activity
Brain Res.
Cited by (87)
Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats
2021, IBRO Neuroscience ReportsCitation Excerpt :Concurrently, the metabolic activity of the STN neurons, reflected by the neuronal density of vGlut2 mRNA (Aymerich et al., 2006) was not different between the 1- and 5-months post-lesion and age-and time-matched control groups. The small alteration in the cross-sectional area of STN neurons observed at 1-month post-lesion was somewhat in contrast to previous studies which reported initial hyperactivity of STN neurons, reflected by increased expression of vGlut2 and COX-1 mRNA (Hirsch et al., 2000; Breit et al., 2001; Aymerich et al., 2006; Jouve et al., 2010). Furthermore, an earlier study reported that after a unilateral SNpc lesion, the firing rate of STN neurons was increased slightly 1 day after the lesion, peaked after 7 days, and was ~190% of control at 14 days (Hirsch et al., 2000).
Development of allosteric modulators of GPCRs for treatment of CNS disorders
2014, Neurobiology of DiseaseThe primate thalamostriatal systems: Anatomical organization, functional roles and possible involvement in Parkinson's disease
2011, Basal GangliaCitation Excerpt :To do so, the line of research led by Kimura and his colleagues aimed at characterizing the physiological responses of CM/PF neurons to attention-related stimuli must be pursued and expanded to nonhuman primate models of PD. Animal studies have, indeed, provided evidence that CM neurons display abnormal physiological activity in parkinsonism [81,136,154–156], but the exact nature of these alterations, and their importance in CM/PF-mediated attention task regulation requires further consideration. The suggestion that CM neuronal loss is a compensatory response to the parkinsonian insult is of interest [157], but awaits further evidence that such a process takes place in the complex scheme of PD pathophysiology.