Elsevier

Microbes and Infection

Volume 5, Issue 8, July 2003, Pages 723-730
Microbes and Infection

Forum in immunology
Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma

https://doi.org/10.1016/S1286-4579(03)00114-XGet rights and content
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Abstract

Host T-cell response to Helicobacter pylori is important for the clinical outcome of the infection. A Th1-polarized response, preferentially against CagA, is associated with peptic ulcer, whereas mixed Th1 and Th0 responses are present in non-ulcer gastritis. A deregulated H. pylori-driven Th0 cell-dependent B-cell activation is found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.

Keywords

Mucosal immunity
Th1–Th2 response
Cytokines
Helicobacter pylori
Chronic gastritis
Peptic ulcer
Gastric cancer
Gastric lymphoma

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