ReviewIn vivo studies of monoclonal anti-D and the mechanism of immune suppression
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Cited by (22)
Fc and Complement Receptors
2015, Molecular Biology of B Cells: Second EditionRh-immunoglobulin: Rh prophylaxis
2006, Best Practice and Research: Clinical HaematologyProduction of recombinant Ig molecules from antigen-selected single B cells and restricted usage of Ig-gene segments by anti-D antibodies
2005, Journal of Immunological MethodsPrevention and management of RhD isoimmunization
2004, Clinics in PerinatologyA single recombinant anti-RhD IgG prevents RhD immunization: Association of RhD-positive red blood cell clearance rate with polymorphisms in the FcγRIIA and FcγIIIA genes
2004, BloodCitation Excerpt :These mechanisms would also not exclude a role for inhibition of specific B cells by FcγRIIB signaling once the RBCs are cleared from the circulation.60 The precise mechanism of action of Rh prophylaxis remains unclear and may depend on multiple additional pathways (reviewed in Kumpel20; Kumpel and Elson52; and Urbaniak and Greiss61). Our study has demonstrated that a single human recombinant IgG1 antibody expressed in CHO cells effectively prevented RhD immunization in male volunteers after a large RBC challenge of a volume not previously tested in other clinical trials of monoclonal anti-RhD antibodies.
Fc and Complement Receptors
2004, Molecular Biology of B Cells
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