Radiobiological and clinical bases for total body irradiation in the leukemias and lymphomas
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Cited by (35)
Radiobiologic Principles and the Role of Radiotherapy in Hematopoietic Cell Transplant and Chimeric Antigen Receptor T-Cell Therapy
2023, Manual of Hematopoietic Cell Transplantation and Cellular TherapiesVolumetric Modulated Arc Therapy Enabled Total Body Irradiation (VMAT-TBI): Six-year Clinical Experience and Treatment Outcomes
2022, Transplantation and Cellular TherapyCitation Excerpt :Similar results were obtained in a recent VMAT-TBI study by Tas et al. [22] in which a higher instantaneous dose rate (ranged 50-600 MU/min, 0.24-0.36 Gy/min) was used and no grade 3+ lung toxicity occurred in any patient (n = 30). Many prior studies have shown that dose rate appears to have little effect on toxicities in fractionated TBI, especially with the reduced dose to the lungs [35–40]. We plan to systematically investigate higher dose rate in future patients with the goal of decreasing treatment time if safe to do so.
Simplified low-dose-rate infant total body irradiation
2017, Practical Radiation OncologyCitation Excerpt :Total body irradiation (TBI) is an important component of conditioning regimens before hematopoietic stem cell transplantation. Radiobiologically, the rationale for low-dose-rate (LDR) TBI (5 to 10 cGy/minute) is that hematopoietic cells demonstrate little sublethal damage repair in comparison to nonhematologic tissue, allowing for improved therapeutic ratio.1 Ozashin et al conducted a randomized study of 157 patients undergoing stem cell transplantation to LDR or high-dose-rate TBI and found high dose rate was associated with increased development of cataracts.2,3
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