Trends in Biochemical Sciences
FrontlinesThe turning point in genome research
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Cited by (128)
Mass spectrometry for determination of bioactive compounds
2014, Comprehensive Analytical ChemistryCitation Excerpt :For an ideal fragmentation process the sequence of a peptide could be simply determined by converting the mass differences of consecutive ions in a spectrum to the corresponding amino acids. This ideal situation would occur if the fragmentation process could be controlled so that each peptide was cleaved between every two consecutive amino acids [28,29]. The application of this technique has been widely used in the identification of several peptides and proteins.
The discovery of novel protein-coding features in mouse genome based on mass spectrometry data
2011, GenomicsCitation Excerpt :As the post-genomic era gains momentum, identifying protein-coding genes remains a fundamental challenge in genome annotation [1]. Historically, data sources based on gene expression (e.g. ESTs library) have provided valuable information for defining the location of encoding genes in genome [2–4]. On the other hand, the method of ab initio gene prediction has been proved to be rather effective in cataloging prokaryote genomes [5–7].
Sequence assembly
2009, Computational Biology and ChemistryCitation Excerpt :Collections of ESTs have given a first good approximation of the diversity of all protein coding genes in a tissue (Christoffels et al., 200). During the years ESTs have become an important tool with many applications, mostly in relation to gene analysis and gene discovery (Boguski, 1995; Marra et al., 1998; Adams et al., 1992, 1993; Nakamura et al., 1997; Medzhitov et al., 1997; Liang et al., 2000b; Hudson et al., 1995; Schuler et al., 1996; Deloukas et al., 1998; Waterston et al., 1992; McCombie et al., 1992; Brody et al., 1995; Kan et al., 2001; Tugendreich et al., 1994; Papadopoulos et al., 1994; Adams et al., 1995; Braren et al., 1997; Allikmets et al., 1995; Nelson et al., 2000; Garg et al., 1999; Buetow et al., 1999; Brett et al., 2000; Mironov et al., 1999; Sorek and Safer, 2003). The amount of data generated by the different sequencing projects is overwhelming.
Comparative Genomics in Eukaryotes
2005, The Evolution of the GenomeComparative Genomics in Eukaryotes
2004, The Evolution of the Genome