Trends in Biochemical Sciences
Protein sequence motifConserved sequence motifs in bacterial and bacteriophage chaperonins
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Cited by (25)
An Expanded Protein Folding Cage in the GroEL-gp31 Complex
2006, Journal of Molecular BiologyLow stability for monomeric human chaperonin protein 10: Interprotein interactions contribute majority of oligomer stability
2002, Archives of Biochemistry and BiophysicsPseudo-T-even Bacteriophage RB49 Encodes CocO, a Cochaperonin for GroEL, which Can Substitute for Escherichia coli's GroES and Bacteriophage T4's Gp31
2001, Journal of Biological ChemistryCitation Excerpt :In the absence of a functional gene 31, the Gp23 capsid protein aggregates in lumps on the E. coli inner membrane (39). The realization that some groEL mutations (but none of the groESmutations) block bacteriophage T4 morphogenesis by interfering with the action of Gp31 led to the proposal that Gp31 may serve as a more specialized GroES-like homolog, capable of assisting the correct folding of Gp23 by GroEL (14, 43) despite the fact that the GroES and Gp31 proteins share little sequence identity (∼14%; Refs. 14-16). Gp31 is indeed a cochaperonin for GroEL; it substitutes for GroES in protein folding, binds GroEL, and modulates its ATPase activity as GroES does and even suppresses the temperature-sensitive phenotype ofgroES mutations (21).
The importance of a mobile loop in regulating chaperonin/co-chaperonin interaction: Humans versus Escherichia coli
2001, Journal of Biological ChemistryCitation Excerpt :Not surprisingly, Gp31 has closer functional similarity to GroES than Hsp10 because it interacts with the same GroEL partner in vivo as GroES. However, GroES and Gp31 share much less sequence similarity (∼14%) than GroES and Hsp10 (∼44%; Ref. 50; Fig.2 A). Since it has been shown that GroES does not assist Hsp60 in refolding substrates because GroES does not bind to Hsp60, then it is likely that elements responsible for the defective partnership lie within the binding interface of the chaperone proteins (23).
Reconstitution of higher plant chloroplast chaperonin 60 tetradecamers active in protein folding
2000, Journal of Biological ChemistryCompensatory changes in GroEL/Gp31 affinity as a mechanism for allele- specific genetic interaction
1999, Journal of Biological Chemistry