Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease
A novel class of CMV protease inhibitors based on a benzothiopyran-S,S-dioxide nucleus has been discovered. Enzyme kinetic data support a reversible mode of inhibition for a representative member of this class, 1
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2022, Journal of Molecular StructureCitation Excerpt :It is observed that thio-derivatives of heterocyclic molecules show higher biological activities than their oxygen counterparts (Fig. 1) [10,11]. Thiocoumarin, for example, shows interesting photochemical [12] as well as biological activities [13] and acts as a building block for the synthesis of natural products and biologically active compounds [14]. Biological activities include TNF-α inhibitor [15], anti-oxidant [16], anti-inflammatory, anti-microbial [17] and carbonic anhydrase inhibition [18].
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