Enhancement of binding of quaternary ammonium derivatives of chlorpromaxine to dopamine D-2 receptors by the addition of a H-bonding group
The synthesis of two aza analogs of the quaternary salt of chlorpromazine along with the evaluation of these analogs on dopamine D-2 receptor is reported. The results indicate it is possible to enhance the binding of the trimethylammonium analog of chlorpromazine to the D-2 receptor by the addition of appropriate hydrogen bonding groups.
References (7)
- et al.
Tet. Lett.
(1972) - et al.
Europ. J. Pharmacol.
(1992) - et al.
J. Med. Chem.
(1981)
There are more references available in the full text version of this article.
Cited by (2)
Studies on the size and stability of chlorpromazine hydrochloride nanostructures in aqueous solution
2001, Biophysical Chemistry
Copyright © 1993 Published by Elsevier Ltd.