Enhancement of binding of quaternary ammonium derivatives of chlorpromaxine to dopamine D-2 receptors by the addition of a H-bonding group

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Abstract

Several permanently charged analogs of chloropromazine were synthesized and evaluated for their binding to dopamine D-2 receptors.

The synthesis of two aza analogs of the quaternary salt of chlorpromazine along with the evaluation of these analogs on dopamine D-2 receptor is reported. The results indicate it is possible to enhance the binding of the trimethylammonium analog of chlorpromazine to the D-2 receptor by the addition of appropriate hydrogen bonding groups.

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