Examination of peptidic α′,β-diamino-α,α-difluoroketones as inhibitors of human leukocyte elastase
The preparation and in vitro evaluation of a series of peptidic α′,β-diamino-α,α-difluoroketones are described. Comparison of the efficacy of these compounds to both their corresponding trifluoromethylketone and α-carboxamido-α,α-difluoroketone inhibitors reveals a divergent set of structure-activity relationships. This divergence indicates that the inhibitor's P1′-amino group is strongly interacting with the enzyme's S1′-subsite.
References (13)
- et al.(1987)
- et al.
J. Am. Chem. Soc.
(1965) - et al.
Med. Res. Rev.
(1994)et al. - et al.
There are more references available in the full text version of this article.
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