The Journal of Steroid Biochemistry and Molecular Biology
Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?*
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Cited by (49)
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2022, Molecular and Cellular EndocrinologyCitation Excerpt :Aromatase cytochrome P450 is the final enzyme in the synthesis of estradiol and estrone from their androgen precursors. The pig genome has three functional paralogous genes encoding aromatase (Choi et al., 1997; Conley et al., 1997; Graddy et al., 2000; Vanselow et al., 2021). The high levels of aromatase found in porcine testes are from expression of CYP19A3 in the Leydig cells although immunohistochemical detection of protein was observed in seminiferous tubules of immunocastrated boars (Srisuwatanasagul et al., 2021).
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2014, Reproductive ToxicologyCitation Excerpt :In the present study, increased CYP19 mRNA levels have been found for all tested concentrations of both flavanones. It has been documented that porcine aromatase exists as three distinct isoforms that arise from multiple genes and complex splicing [66]. In contrast, human aromatase is encoded by a single gene and displays tissue-specific expression that arises from alternate promoter usage [67].
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Proceedings of the IV International Aromatase Conference, Tahoe City, CA, U.S.A., 7–11 June 1996.