Original articleFeto-maternal distribution of ropivacaine and bupivacaine after epidural administration for cesarean section
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2011, European Journal of Pain SupplementsCitation Excerpt :Ropivacaine rapidly crosses the placenta during epidural administration for Cesarean section, resulting in near complete equilibrium of the free fraction of ropivacaine in the maternal and fetal circulation. However, the degree of plasma protein binding is less in the fetus than the mother resulting in lower total plasma concentrations in the fetus than the mother (Ala-Kokko et al., 1997). Ropivacaine is metabolized extensively in the liver.
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