Synthesis of (R)-cyanohydrins by crude (R)-oxynitrilase-catalyzed reactions in micro-aqueous medium

doi:10.1016/S0957-4166(98)00177-3

Tetrahedron: Asymmetry

Volume 9, Issue 11, 5 June 1998, Pages 1835-1838

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Abstract

In diisopropyl ether or ethyl acetate under micro-aqueous conditions, the enantioselective synthesis of (R)-cyanohydrins from aldehydes and methyl ketones was studied using crude (R)-oxynitrilase prepared from almonds. This reaction system performed well over the temperature range of 4°C to 30°C.

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Acknowledgements

The authors thank the National Natural Science Foundation of China for financial support and professor Lijun Xia, Ms. Minhua Tang for performing the HPLC analysis.

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