Regular paperIdentification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene
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The DIG User's Guide for Filter Hybridation
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The clinical value of Fibulin-1 for prognosis and its prospective mechanism in intrahepatic cholangiocarcinoma
2019, HPBCitation Excerpt :Fibulin-1, a widespread component of the extracellular matrix (ECM), can mediate cell signal transduction events by binding to ECM proteins, such as laminin-1, fibronectin, and versican. Fibulin-1 has been reported able to regulate cell morphology, adhesion, growth and mobility.4–7 More importantly, Fibulin-1 is up-regulated in ovarian and breast carcinomas, and the expression level is related to tumor progression in breast, ovarian and prostate cancers.8–10
Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology
2015, Pharmacological ResearchDistinct regions within fibulin-1D modulate interactions with hemicentin
2012, Experimental Cell ResearchCitation Excerpt :Three anaphylatoxin repeats precede the tandem EGF repeats in fibulins 1 and 2. Two alternate splicing events within the C. elegans fibulin-1 gene produce distinct carboxy terminal FC modules and second EGF repeats in fibulin-1C and fibulin-1D [9,10]; Fig. 1. Although no specific function has been identified for the second EGF of fibulin-1D (EGF2D), the second EGF of fibulin-1C (EGF2C) is necessary to rescue the growth and body size defects of a fibulin-1 null mutant and the synthetic larval arrest defect of a fibulin-1; gon-1 double mutant, suggesting that it may have growth factor, or growth factor binding activity [14].
Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development
2012, Developmental BiologyCitation Excerpt :Interestingly, of all vertebrate fibulins, only Hemicentin and Fibulin 1 are present in C. elegans. For Fibulin 1, structural conservation even extends to the Fbln1C and Fbln1D splice isoforms (Barth et al., 1998). Most strikingly, Hmcn and the two Fbln1 isoforms display specific interactions during multiple processes of nematode development (Muriel et al., 2005; Vogel et al., 2006).
ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression
2009, Developmental CellCitation Excerpt :Fibulin-1, a modular ECM protein interacting with the G3 domain of versican, was previously reported to be a cofactor for ADAMTS1 proteolysis of aggrecan (Lee et al., 2005). In addition, the C.elegans fibulin gene, which is most closely related to mammalian fibulin-1 (Barth et al., 1998), interacts genetically with the ADAMTS proteases Mig-17 and Gon-1 during gonadal morphogenesis (Hesselson et al., 2004; Kubota et al., 2004). Versican and fibulin-1 localization was analyzed by immunofluorescence in E14.5 wt and Adamts5−/−;bt/bt hindlimbs.