ArticleÉrythropoïétine et neuroprotectionErythropoietin and neuroprotection
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Erythropoietin, erythropoiesis and beyond
2011, Biochemical PharmacologyCitation Excerpt :At the same time, Shi et al. showed in a rabbit model that the rapid activation of potassium channels and protein kinases by EPO represents an important new mechanism for increasing cardioprotection [115]. Primary investigations on the signaling pathways involved in EPO-mediated cardioprotection demonstrated the phosphorylation and activation of JAK1/2, STAT3, STAT5a and PI3K as well as the activation of PKCɛ, RAF, MEK1/2, p42/44-MAPK and p38-MAPK [116] (Fig. 3). The cardiac inflammation and apoptosis of myocardial cells are two distinct phenomena in the deterioration of cardiac function, but both are triggered during I/R or MI.
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