n-3 polyunsaturated fatty acids as pharmacologic agents: A fishy tale?
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Effects of ω-3 fatty acids on leukocyte Th1/Th2 cytokine and integrin expression in rats with gut-derived sepsis
2007, NutritionCitation Excerpt :A study by Zhang et al. [3] showed that the anti-inflammatory effect of FO was due to the suppression of T-helper type 1 (Th1) cytokine production. Dietary FO has been shown to have beneficial clinical effects on Th1-mediated diseases including rheumatic arthritis, ulcerative colitis, Crohn’s disease, multiple sclerosis, and insulin-dependent diabetes mellitus [2,4]. However, some studies have found that FO supplementation suppresses lymphocyte proliferation and interleukin (IL)-2 production and has immunosuppressive properties [5,6].
Different edible oil beneficial effects (canola oil, fish oil, palm oil, olive oil, and soybean oil) on spontaneously hypertensive rat glomerular enlargement and glomeruli number
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2003, Food and Chemical ToxicologyDo ω-3 fatty acids ease the way to silent cell death?
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2001, Critical Care ClinicsCitation Excerpt :Perhaps this effect is partially mediated by n-3 PUFA-induced decreases in PGE2. In contrast, the effect of n-3 PUFA on TNF production by elicited peritoneal macrophages (e.g., thioglycolate, casein) is variable, with studies reporting no effect, reduction, or enhancement.18,19 These studies using elicited macrophages report decreases in IL-1.