Elsevier

Hand Clinics

Volume 16, Issue 2, May 2000, Pages 271-287
Hand Clinics

THERMAL INJURIES
MOLECULAR AND CELLULAR ASPECTS OF FIBROSIS FOLLOWING THERMAL INJURY

https://doi.org/10.1016/S0749-0712(21)00203-1Get rights and content

SUMMARY

The pathogenesis of hypertrophic scars following thermal injury remains a complex and incompletely understood process but recent investigations into the composition of the tissue itself, the activities of the scar fibroblasts, and the effects of various cytokines and growth factors, have all contributed to the emergence of an increasingly clear picture. Although it may be considered just one example of a broad range of fibroproliferative disorders that afflict many different organs, often in response to diverse environmental insults, the nature of the burn injury and the special properties of skin probably play important roles in promoting the development of this especially troublesome variety of excessive connective tissue. This knowledge has provided the rationale for a number of experimental therapies that, individually or in some combination, may augment or one day supplant the more commonly employed surgical or physical treatments.

References (139)

  • GR Grotendorst

    Connective tissue growth factor: A mediator of TGF-β action on fibroblasts

    Cytokine Growth Factor Rev

    (1997)
  • AR Harrop et al.

    Effect of α-interferon on cell proliferation, collagen production and procollagen mRNA expression in hypertrophic scar fibroblasts in vitro

    J Surg Res

    (1995)
  • T Hayakawa et al.

    Changes in type of collagen during the development of human post-burn hypertrophic scars

    Clin Chim Acta

    (1979)
  • A Igarashi et al.

    Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid and other fibrotic skin disorders

    J Invest Dermatol

    (1996)
  • RA Ignotz et al.

    Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix

    J Biol Chem

    (1986)
  • V-M Kahari et al.

    Differential regulation of extracellular matrix proteoglycan (PG) gene expression

    J Biol Chem

    (1991)
  • T Kanzaki et al.

    TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

    Cell

    (1990)
  • KP Karey et al.

    Human platelet-derived mitogens: Subcellular localization of insulin-like growth factor-1 to the alpha granule and release in response to thrombin

    Blood

    (1989)
  • EJ Kovacs

    Fibrogenic cytokines: The role of immune mediators in the development of scar tissue

    Immunol Today

    (1991)
  • FE Krotzsch-Gomez et al.

    Cytokine expression is down-regulated by collagen-polyvinylpyrrolidone in hypertrophic scars

    J Invest Dermatol

    (1998)
  • IM Kuc et al.

    Ultrastructure of the bovine temporomandibular joint disc

    Arch Oral Biol

    (1994)
  • HA Linares et al.

    The histiotypic organization of the hypertrophic scar in humans

    J Invest Dermatol

    (1972)
  • JE Meredith et al.

    Integrins, adhesion and apoptosis

    Trends Cell Biol

    (1997)
  • A Moren et al.

    Identification and characterization of LTBP-2, a novel latent transforming growth factor-β-binding protein

    J Biol Chem

    (1994)
  • Y Oh et al.

    Transforming growth factor-β–induced cell growth inhibition in human breast cancer cells is mediated through insulin-like growth factor binding protein-3

    J Biol Chem

    (1995)
  • R Okazaki et al.

    Transforming growth factor and forskolin increase all classes of insulin-like growth factor-1 transcripts in normal osteoblast-like cells

    Biochem Biophys Res Communs

    (1995)
  • C Overall et al.

    Independent regulation of collagense, 72 kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-β

    J Biol Chem

    (1989)
  • AF Purchio et al.

    Identification of mannose-6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor β-1 precursor

    J Biol Chem

    (1988)
  • J Peltonen et al.

    Activation of collagen gene expression in keloids: Colocalization of type I and VI collagen and transforming growth factor β-1 mRNA

    J Invest Dermatol

    (1991)
  • E Adachi et al.

    In vitro formation of hybrid fibrils of type V collagen and type I collagen. Limited growth of type I collagen into thick fibrils by type V collagen

    Connect Tissue Res

    (1986)
  • MM Al-Khawajah

    Failure of interferon α-2b in the treatment of mature keloids

    Int J Dermatol

    (1996)
  • JE Albina et al.

    Nitric oxide-mediated apoptosis in murine peritoneal macrophages

    J Immunol

    (1993)
  • JB Allen et al.

    Suppression of monocyte function and differential regulation of IL-1 and IL-4 contribute to resolution of experimental arthritis

    J Immunol

    (1993)
  • M Arakawa et al.

    Reduced collagenase gene expression in fibroblasts from hypertrophic scar tissue

    Br J Dermatol

    (1996)
  • A Barreca et al.

    In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors

    J Cell Physiol

    (1992)
  • PS Baur et al.

    The observation of myofibroblasts in hypertrophic scars

    Surg Gynecol Obstet

    (1975)
  • P Bianco et al.

    Expression and localization of the two small proteoglycans, biglycan and decorin, in developing human skeletal and nonskeletal tissues

    J Histochem Cytochem

    (1990)
  • JLE Bird et al.

    Dexamethasone potentiates the stimulatory effect of insulin-like growth factor-1 on collagen production in cultured human fibroblasts

    J Endocrinol

    (1994)
  • DE Birk et al.

    Collagen type I and type V are present in the same fibril in the avian corneal stroma

    J Cell Biol

    (1988)
  • DE Birk et al.

    Collagen fibrillogenesis in vitro: Interaction of types I and V collagen regulates fibril diameter

    J Cell Sci

    (1990)
  • SP Blatti et al.

    Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells

    Proc Natl Acad Sci USA

    (1988)
  • WA Border et al.

    Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

    Nature

    (1992)
  • DM Bradham et al.

    Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10

    J Cell Biol

    (1991)
  • RR Bruns et al.

    Type VI collagen in extracellular, 100-nm periodic filaments and fibrils: Identification by immunoelectron microscopy

    J Cell Biol

    (1986)
  • A Castilla et al.

    Transforming growth factors β-1 and α in chronic liver disease. Effects of interferon-α therapy

    N Engl J Med

    (1991)
  • CA Cochrane et al.

    Effect of growth factors on the characteristics of cells associated with equine wound healing and sarcoid formation

    Wound Rep Reg

    (1996)
  • KG Danielson et al.

    Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility

    J Cell Biol

    (1997)
  • PA Dennis et al.

    Cellular activation of latent transforming growth factor-β requires binding to the cation-independent mannose-6-phosphate/insulin-like growth factor type II receptor

    Proc Natl Acad Sci USA

    (1991)
  • A Desmouliere et al.

    Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar

    Am J Pathol

    (1995)
  • KN Dolynchuk et al.

    Topical putrescine (Fibrostat) in the treatment of hypertrophic scars: Phase II study

    Plast Reconstr Surg

    (1996)
  • Cited by (0)

    This work was supported by Grant Numbers MT 11768, MT 12536, and MT 13387 from the Medical Research Council of Canada.

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