Original articleColorectal cancer in patients over 75 years of age—determinants of outcome
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The influence of age on the outcome of treatment of elderly patients with colorectal cancer
2014, Journal of Geriatric OncologyCitation Excerpt :It was also the case that the elderly were more often females and had worse ASA scores. Studies have concluded that, after controlling for other risk factors, the early post-operative mortality in the elderly is not much different to that in the younger patients.4,20–30 However, in our study of older patients, as in some other recent larger studies,16,31–38 after adjusting for key risk factors, age itself was found to be an independent risk factor for 30-day and 6-month mortality.
Survival outcome of operated and non-operated elderly patients with rectal cancer: A Surveillance, Epidemiology, and End Results analysis
2014, European Journal of Surgical OncologyCitation Excerpt :This may lead to better use of maximum therapy leading to best oncological outcome in those deemed fit, and also increase the proportion of downstaged cancer suitable for local excision. This study was unable to adjust for differences in comorbidity associated with increasing age, including pre-operative frailty and peri-operative anaesthetic risk, both of which further influence survival.22 The impact of changing prevalence and severity of comorbidities at different ages has implications for targeted research into clinical and psychosocial interventions.23
Surgical Management of Colon Cancer
2012, Colorectal SurgeryThe survival gap between middle-aged and elderly colon cancer patients. Time trends in treatment and survival
2011, European Journal of Surgical OncologyCitation Excerpt :Although, in the present study we could not confirm the higher stage at diagnosis, but more elderly patients were registered with an unknown stage of disease which could include undiagnosed stage III and IV. Elderly patients are also less likely to receive adjuvant treatment and receive “suboptimal” management.22–27 Adjuvant chemotherapy has shown to be an effective treatment for elderly patients with stage III colon cancer, but the benefit is lower with older age.18,28,29
The United Kingdom National Bowel Cancer Project - Epidemiology and surgical risk in the elderly
2007, European Journal of CancerCitation Excerpt :In addition, in the event that elderly patients should require management in Intensive Care (ITU) postoperatively, it has been noted that their risk of additional complications such as anastomotic leakage is significantly higher.31 Radical surgery may not be the treatment of choice in this age group, with post-operative function and QoL, rather than cancer cure, being of relatively greater importance.32–35 If medical palliation, expectant management and colonic stenting for CRC are performed in favour of surgery, then this patient group will inevitably present as emergencies should their disease progress, and this may in part be reflected in the present results.
Metastatic colorectal cancer
2006, Cancer Treatment Reviews