Clinical StudiesChronic l-arginine treatment increases cardiac cyclic guanosine 5′-monophosphate in rats with aortic stenosis: effects on left ventricular mass and beta-adrenergic contractile reserve☆
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Abbreviations
ACE
angiotensin-converting enzyme
BW
body weight
[Ca2+]i
intracellular calcium
GMP
guanosine 5′-monophosphate
LV
left ventricular
LV devP
left ventricular developed pressure
LV dP/dt
first derivative of left ventricular pressure
LVEDP
left ventricular end-diastolic pressure
LVH
left ventricular hypertrophy
LVSP
left ventricular systolic pressure
NO
nitric oxide
NOS
nitric oxide synthase
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This study was supported in part by Grant HL-38189 (BHL and EOW) from the National Heart, Lung and Blood Institute, Bethesda, Maryland and by the fellowship award F05 TW05261-01 from the Fogarty International Center, National Institutes of Health, Bethesda, Maryland (JB).
Copyright © 1998 American College of Cardiology. Published by Elsevier Inc. All rights reserved.