Experimental studyRegulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-adrenergic receptors☆
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Abbreviations
ANF
atrial natriuretic factor
AR
adrenergic receptor
βARK1
βAR kinase-1
CAM
constitutively activated mutant
cAMP
cyclic adenosine monophosphate
du
densitometry units
GPCR
G protein-coupled receptor
GRK
G protein-coupled receptor kinase
HF
heart failure
mRNA
messenger ribonucleic acid
NLC
nontransgenic littermate control
PE
phenylephrine
SERCA2a
sarcoplasmic reticulum Ca++-ATPase
Tgα43
transgenic mice with cardiac targeted overexpression of the wild-type α1B-AR
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This work was supported in part by the National Institutes of Health grants HL-16037 (R.J.L.), HL-61690 (W.J.K.) and fellowships from the North Carolina Affiliate of the American Heart Association (G.I.) and Telethon Fondazione Onlus (G.I.). Robert J. Lefkowitz is an investigator at the Howard Hughes Medical Institute.
Copyright © 2001 American College of Cardiology. Published by Elsevier Inc. All rights reserved.