Neuropeptides and Their Role in Nociception and Analgesia
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Randomized evaluation of octreotide vs prochlorperazine for ED treatment of migraine headache
2009, American Journal of Emergency MedicineCitation Excerpt :Our results demonstrate a superiority of PC over OC in treatment of headaches meeting the definition of migraines according to the International Heachache Society criteria. Somatostatin is known to have an inhibitory effect on a number of neuropetides, inhibits serotonin, bradykinin, prostaglandins, substance P, and vasoactive intestinal peptide, all which have been implicated in migraine [15-17]. Native somatostatin is an unstable compound and is broken down in minutes.
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