Short communicationColourimetric and AAS determination of cephalosporins using Reineck's salt
Introduction
Cephalosporins are penicillinase-resistant antibiotics with significant activity against Gram positive and Gram negative bacteria [1]. Cephalosporins were determined by titrimetric [2], [3], [4], [5], spectrophotometric [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], fluorimetric [17], [18], [19], [20], chromatographic [21], [22], [23], [24], [25], potentiometric [26] and polarographic [27], [28] methods.
Reineck's salt is ammonium tetrathiocyanotodiamminochromate (III) monohydrate in which it can be used for quantitative determination of many pharmaceutical compounds applying gravimetric [29], titrimetric [30] and spectrophotometric [31], [32], [33], [34], [35] procedures.
The purpose of the present work is to describe the development of the two simple and accurate spectrophotometric procedures, as well as a selective and sensitive atomic absorption spectrometric procedure, for the analysis of the titled antibiotic in the pure form as well as in pharmaceutical preparations.
Section snippets
Apparatus
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A Shimadzu UV1601, UV-visible spectrophotometer (Tokyo, Japan).
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A Shimadzu atomic absorption flame spectrophotometer model AA.640-13 with a chromium hollow cathode lamp under the following observation height above burner 1 cm; single slot type burner; air flow-rate 21.51/min; acetylene flow-rate 3.41/min operation conditions: lamp current 29 mA; slit width 0.7 nm; wavelength current 29 mA; slit width 0.7 nm; wavelength 358.6 nm.
Materials
All solvents and reagents were of analytical reagent grade.
Results and discussion
Mixing each aqueous solution of cephaprin sodium, cefuroxime sodium, cefotaxime sodium, cefoperazone sodium, cefadroxil, ceftazidime, cefazolin sodium or cefaclor with ammonium reineckate in acidic medium at 25±2 °C resulted in the formation of red precipitate. It is based on the formation of ion-pair complexes between the drugs and ammonium reineckate.
Formation of drug-reineckate ion-pair complexes allows indirect determination of these drug by atomic absorption spectrometric measurement of the
References (37)
- et al.
J. Pharm. Biomed. Anal.
(1997) - et al.
J. Chromatogr. Biomed. Appl.
(1998) - et al.
J. Pharm. Biomed. Appl.
(1999) - et al.
J. Pharm. Biomed. Appl.
(1999) - et al.
J. Pharm. Sci.
(1981) - Wilson and Gisfold's Text Book of Organic Medicinal and Pharmaceutical Chemistry, tenth ed., J.B. Lippincott, Raven,...
- et al.
Anal. Chim. Acta
(1979) - et al.
Analyst
(1982) - et al.
Pharmazie
(1988) - et al.
Chem. Anal.
(1997)
Anal. Lett.
Anal. Lett.
Anal. Lett.
Mikrochim. Acta
Spec. Lett.
J. Assoc. Off. Anal. Chem.
Indian Drugs
Analyst
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