Research paperBioequivalence study of carbamazepine tablets: In vitro/in vivo correlation
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2021, Journal of Pharmaceutical SciencesCitation Excerpt :The performance of different SLS concentrations has also been assessed where one report showed that SLS 0.5% enabled successful prediction of plasma-time profiles,50 while other work displayed the best predictions with SLS 0.1%.63 Conversely, only one study reported that neither SLS nor HCl media correlated well with AUC parameter.97 The results from the literature agree that best correlations were obtained when using fraction dissolved (Fd) within 30–90 min.
Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review
2015, Journal of Pharmaceutical AnalysisCitation Excerpt :CBZ is available in market with the brand names Carbamazepen, Carbatrol, Carbazepine, Carbelan and Epitol. Although CBZ is poorly soluble in aqueous media, it has a high oral bioavailability in humans [4]. Metabolism occurs primarily in the liver via the cytochrome P-450 oxidase system, producing carbamazepine-l0, 11-epoxide (CBZ-EP) which is as active and may reach a level up to half that of CBZ.
Comparative in vitro dissolution study of carbamazepine immediate-release products using the USP paddles method and the flow-through cell system
2014, Saudi Pharmaceutical JournalCitation Excerpt :In the present study, carbamazepine official dissolution test was not discriminating enough, all commercial products used reached the dissolution criteria (Test 3) and the dissolution profiles of the generic products were similar to the dissolution profile of the reference product. For different carbamazepine formulations Girad et al. (1996) reported a faster dissolution when 1.0% sodium lauryl sulfate aqueous solution was used together with the USP paddles method however, simulated intestinal fluid pH 7.5 was more discriminative between products; Castro and Jung (2000) demonstrated that the USP dissolution test cannot be used to predict the bioavailability of commercial products and Jung et al. (1997) reported that no correlation was found between in vitro dissolution data, obtained with the USP paddles method, and in vivo parameters. On the other hand, Hamlin et al. (1962) hypothesized and later proved that products differing significantly in in vivo performance would not show in vitro differences if the dissolution test was conducted at a high agitation rate.
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