One of the major challenges in denotational semantics is the construction of a fully abstract semantics for a higher-order sequential programming language. For the past fifteen years, research on this problem has focused on developing a semantics for PCF, an idealized functional programming language based on the typed λ-calculus. Unlike most practical languages, PCF has no facilities for observing and exploiting the evaluation order of arguments to procedures. Since we believe that these facilities play a crucial role in sequential computation, this paper focuses on a sequential extension of PCF, called SPCF, that includes two classes of control operators: a possibly empty set of error generators and a collection of catch and throw constructs. For each set of error generators, the paper presents a fully abstract semantics for SPCF. If the set of error generators is empty, the semantics interprets all procedures-including catch and throw-as Berry-Curien sequential algorithms. If the language contains error generators, procedures denote manifestly sequential functions. The manifestly sequential functions form a Scott domain that is isomorphic to a domain of decision trees, which is the natural extension of the Berry-Curien domain of sequential algorithms in the presence of errors.