Elsevier

Neuroscience Letters

Volume 253, Issue 2, 4 September 1998, Pages 135-138
Neuroscience Letters

The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission

https://doi.org/10.1016/S0304-3940(98)00629-6Get rights and content

Abstract

The effects of the anti-narcoleptic drug modafinil (30–300 mg/kg i.p.) on GABA and glutamate release were evaluated in the basal ganglia of the conscious rat, by using the microdialysis technique. Modafinil (100 mg/kg) inhibited striatal (85±4% of basal values) and pallidal (85±2%) GABA release without influencing local glutamate release. At the highest dose (300 mg/kg), modafinil induced a further reduction of pallidal (75±2%) but not striatal (82±7%) GABA release and increased striatal (134±11%) but not pallidal glutamate release. On the contrary, in the substantia nigra modafinil reduced GABA release only at the 300 mg/kg dose (59±5%) without affecting glutamate release. The preferential reduction in striato-pallidal GABA release at the 100 mg/kg dose of modafinil suggests that modafinil may be useful in the treatment of Parkinsonian diseases.

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