Dextrorphan attenuates responses of spinothalamic tract cells in normal and nerve-injured monkeys
Section snippets
Acknowledgements
The authors would like to thank Brenda Kenworthy for her secretarial help in preparing the manuscript. The work was supported by NIH grants NS11255, NS27910 (SMC) and NS09743 (WDW) and a Human Frontier Research Fellowship (HR).
References (24)
- et al.
Potentiation of morphine-induced antinociception in acute spinal rats by the NMDA antagonist dextrorphan
Brain Res.
(1995) - et al.
Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
Pain
(1988) Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity
Brain Res.
(1987)- et al.
Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids
Eur. J. Pharmacol.
(1985) - et al.
Dextromethorphan attenuates and reverses analgesic tolerance to morphine
Pain
(1994) - et al.
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy
Brain Res.
(1993) - et al.
The N-methyl-d-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man
Pain
(1994) - et al.
Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat
Neurosci. Lett.
(1993) - et al.
Inhibition of opiate tolerance by non-competitive N-methyl-d-aspartate receptor antagonists
Brain Res.
(1994) - et al.
An instrument using a multiple layer Peltier device to change skin temperature rapidly
Brain Res. Bull.
(1984)
Dextromethorphan: an overview of safety issues
Drug Safety
Comparative pharmacology of levorphan, racemorphan, dextrorphan and related methyl ethers
J. Pharmacol. Exp. Ther.
Cited by (15)
The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates
2004, PainCitation Excerpt :The present study also confirms that tight ligation of spinal nerve L7 in primates leads to increased responsiveness of STT neurons to mechanical and thermal stimuli in the spinal segments just rostral to L7 (Palecek et al., 1992). The electrophysiological data, together with behavioral findings demonstrating enhanced responses to innocuous stimuli (Carlton et al., 1994, 1997, 1998), are consistent with the presence of allodynia in these spinal nerve-lesioned animals. Blocking kainate receptors in awake, behaving animals could conceivably be antiallodynic and antihyperalgesic, as shown for peripheral inflammation with complete Freunds adjuvant in rats (Guo et al., 2002).
The induction of pain: An integrative review
1999, Progress in Neurobiology