Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy
References (20)
- et al.
Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial
Eur. J. Cancer
(1995) - et al.
Treatment of colorectal cancer metastases confined to the liver
Eur. J. Cancer
(1995) - et al.
p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
Blood
(1994) - et al.
Colorectal cancer; hepatic-directed therapy: the role of surgery, regional chemotherapy, and novel modalities
- et al.
Long-term survivors of colorectal cancer with unresectable hepatic metastases
Dis. Colon Rect.
(1985) - et al.
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
Cancer Res.
(1992) - et al.
Colorectal cancer biology: clinical implications
- et al.
The role of thymidylate synthase expression in the prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
J. Clin. Oncol.
(1994) - et al.
p53 status and thymidylate synthase levels are predictors of chemotherapy efficacy in patients with advanced colorectal cancer
- et al.
Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival
J. Clin. Oncol.
(1996)
Cited by (88)
Proteomic analysis of acute radiation-induced rectal injury in rats
2023, Radiation Medicine and ProtectionAdministration of adjuvant oral tegafur/uracil chemotherapy post hepatocellular carcinoma resection: A randomized controlled trial
2016, Asian Journal of SurgeryCitation Excerpt :Theoretically, the lower activities of TS and DPD in tumors produce the better response to 5-FU.20–22 In fact, low TS patients who received hepatic artery infusion chemotherapy had 4.1 times higher response for colorectal liver metastases than those of high TS patients.23 Furthermore, in patients with neck and head cancer, complete responders had a significantly lower DPD activity than those of partial or no responders.24
Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: Results of a randomised multicentre trial
2012, European Journal of CancerCitation Excerpt :Several studies in mCRC demonstrated that high intratumoural TS levels correlated with resistance to fluoropyrimidine treatment.8,9 Similar observations were reported for liver metastases of CRC treated with fluoropyrimidine-based hepatic arterial infusion and other gastrointestinal malignancies.10–13 Despite these promising results as a predictor of response to 5-FU based chemotherapy TS has not been recommended for routine clinical practise nor have other markers.14
Improving the Efficacy and Safety of Anticancer Agents - the Role of Pharmacogenetics
2006, Novel Anticancer AgentsMolecular predictors of lymph node metastasis in colon cancer: Increased risk with decreased thymidylate synthase expression
2005, Journal of Gastrointestinal SurgeryCitation Excerpt :Previous studies examining the prognostic role of TS expression have reached somewhat conflicting results. There is some suggestion that cancers with higher levels of TS expression are associated with poorer survival and a poorer response to adjuvant chemotherapy.14–17 There are, however, a number of studies that have shown improved prognosis with higher TS expression, in agreement with our data.18,19
Are colon and rectal cancer two different tumor entities? A proposal to abandon the term colorectal cancer
2018, International Journal of Molecular Sciences