Tumor growth, weight loss and cytokines in SCID mice
References (23)
- et al.
Cancer cachexia is transmissible in plasma
J. Surg. Res.
(1992) - et al.
Interleukin-1 receptor antagonist (IL-1ra) is unable to reverse cachexia in rats bearing an ascites hepatoma (Yoshida AH-130)
Cancer Lett.
(1995) - et al.
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6
Immunobiology
(1993) A review of cancer cachexia and abnormal glucose metabolism in humans with cancer
J. Am. Coll. Nutr.
(1992)- et al.
Mechanisms mediating cancer cachexia
Cancer
(1995) Management of cancer cachexia
- et al.
Humoral mediation for cachexia in tumour-bearing rats
Br. J. Cancer
(1993) - et al.
Parabiotic transfer of cancer anorexia/cachexia in male rats
Cancer Res.
(1985) - et al.
Cytokines and their role in the pathophysiology of cancer cachexia
J. Parenteral Enteral Nutr.
(1992) - et al.
The role of cytokines in cancer cachexia
J. Parenteral Enteral Nutr.
(1992)
Role of endogenous tumor necrosis factor-α and interleukin-1 for experimental tumor growth and the development of cancer cachexia
Cancer Res.
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2023, International Journal of Biochemistry and Cell BiologyCitation Excerpt :When we look at the weights of mice in the absence of tumors, EBR and the vehicle did not affect mice weights. Although it looks like there were no significant changes in the weight of mice in the presence of tumors, mice lost weight to support tumor growth while tumor volume kept expanding (Murray et al., 1997). CEA is a well-known marker for cancer activity and can be detected in blood serum.
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2007, Clinical NutritionCitation Excerpt :The underlying mechanism(s) appears to involve the induction of muscle-specific ubiquitin ligases by catabolic hormones, such as the glucocorticoids, but also the inhibition of anabolic pathways as those controlled by insulin-lide growth factor-1, phosphatidylinositol-3-kinase/Akt, and mammalian target of rapamycin.78 Several cytokines, including tumor necrosis factor-alpha, IL-6, IL-1-beta and gamma interferon, reproduce symptoms of cachexia in animal models, although individually they have not be shown to produce full-blown cachexia syndrome.79 Direct infusion of IL-6 into a mouse muscle decreased myofibrillar protein by 17% at 14 days, suggesting a direct effect on muscle.80
Treatment of lycorine on SCID mice model with human APL cells
2007, Biomedicine and PharmacotherapyCitation Excerpt :With National Cancer Institute (NCI) criteria, T/C exceeding 125% and ILS exceeding 25% indicate that the drug has significant anti-tumor activity [21]. To evaluate the toxicity and side-effect of lycorine on mice, the weight of mice was monitored at day 0, 14, 21, and 28 as described previously [22]. All SCID mice bearing human leukemia were sacrificed painlessly when mice were close to death.
Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance
2006, Cancer LettersCitation Excerpt :We found that LNCaP-CR tumor-bearing mice significantly lost their body weight (Fig. 2). Several cytokines including IL-1, IL-6, TNF-α, leptin, and INF-γ are considered to be mediators of cachexia [9–11]. Our preliminary experiments also revealed that expressions of these cytokines were very low and there were not any difference of their expressions between LNCaP-CR cells and the parental LNCaP cells.
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2004, Principles of Medical BiologyCitation Excerpt :TNFα, IL1β, IL6 and IFNγ production have been implicated in the weight loss and cachexia induced by malignant tumors (Argiles & Lopez Soriano, 1997). Implantation of Morris 7777 hepatoma cells in SCID mice induces TNFα, IL-1β and IL6 production from spleen cells and is associated with profound weight loss (Murray et al., 1997). In contrast, transplantation of MCA sarcoma was not associated with loss or increased proinflammatory cytokine expression (Murray et al., 1997).