Elsevier

Vaccine

Volume 14, Issue 14, October 1996, Pages 1331-1339
Vaccine

Paper
Effects of repeated annual influenza vaccination on vaccine sero-response in young and elderly adults

https://doi.org/10.1016/S0264-410X(96)00058-8Get rights and content

Abstract

Three cohort studies in adults were performed during the periode from 1986 to 1989. Eight hundred and eighty-four subjects were, one or more times, immunized with influenza vaccines, and pre- and post-vaccination antibody titres were determined by hemagglutination inhibition tests. One thousand and one hundred and nineteen vaccination events in 681 subjects could be analysed by a comparison, per trial and per influenza (sub) type, between groups with and without influenza vaccination in previous years. Effect size, odds ratio and protection rate difference, were used as effect measures. Subjects with previous vaccination showed higher pre-vaccination antibody than those without. The average change of the post-vaccination proportion of subjects with high antibody titre value to previous vaccination, was +9.4% (95% CI: +5.3 to 13.6%) for A-H3N2 vaccine components, −2.1% (−8.1 to 3.9%, not significant) for A-H1N1 and −10.6% (−16.5% to −4.8%) for B. In a linear regression model, pre-vaccination titres and the status of previous vaccination were identified as factors significantly influencing post-vaccination titres. These findings are discussed in the context of a short review of the literature. It is concluded that the status of previous vaccination should always be addressed as an independent factor in serological vaccination studies.

References (30)

  • A.P. Kendal et al.

    Antigenic similarity of influenza A(H1N1) viruses from epidemics in 1977–1978 to “Scandinavian” strains isolated in epidemics of 1950–1951

    Virology

    (1978)
  • R. Pyhälä et al.

    HI antibody kinetics in adult volunteers immunized repeatedly with inactivated trivalent influenza vaccine in 1990–1992

    Vaccine

    (1994)
  • K.G. Nicholson

    Annual vaccination: conclusions and recommendations

  • W.A. Keitel et al.

    Efficacy of sequential annual vaccination with inactivated influenza virus vaccine

    Am. J. Epidemiol.

    (1988)
  • P.A. Gross et al.

    Benefit of annual influenza immunization in patients with cystic fibrosis

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