Dapsone in prevention of recurrent neutrophilic eccrine hidradenitis

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Abstract

Neutrophilic eccrine hidradenitis has been described in patients with acute myelogenous leukemia and other malignant diseases, usually during chemotherapy. We describe a 46-year-old man with Hodgkin's disease in whom neutrophilic eccrine hidradenitis developed after each of the first two treatments with lomustine. Dapsone, 100 mg daily, was initiated 48 hours before the patient's third treatment with lomustine and was continued for 14 days. This regimen was successful in suppressing the reaction during the first course and three subsequent courses of lomustine.

References (28)

  • A Nikkels et al.

    Neutrophilic eccrine hidradenitis: a case report

    Acta Clin Belg

    (1993)
  • J Scherbenske et al.

    Asymptomatic erythematous papules in a leukemic patient

    Neutrophilic eccrine hidradenitis

    Arch Dermatol

    (1990)
  • D Margolis et al.

    Neutrophilic eccrine hidradenitis: a case report and review of the literature

    Cutis

    (1991)
  • E Katsanis et al.

    Neutrophilic eccrine hidradenitis in acute myelomonocytic leukemia

    Am J Pediatr Hematol Oncol

    (1987)
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    This article is made possible through an educational grant from the Dermatological Division, Ortho Pharmaceutical Corporation.

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