Journal of the American Academy of Dermatology
Drug-induced linear IgA bullous dermatosis after vancomycin discontinuance in a patient with renal insufficiency☆,☆☆,★
Section snippets
CASE REPORT
A 65-year-old man was admitted to Kings Daughters Hospital (Madison, Ind) after an acute anteroseptal myocardial infarction. He was subsequently transferred to Jewish Hospital (Louisville, Ky) for evaluation for cardiac surgery. His past medical history included a previous myocardial infarction, hypertension, hypercholesterolemia, and chronic obstructive pulmonary disease. Medications on admission were clonidine hydrochloride and hydrochlorothiazide.
Three days after transfer, he underwent an
DISCUSSION
LABD is an autoimmune subepidermal vesiculobullous disease that is characterized histopathologically by the linear deposition of IgA at the BMZ. Multiple medications have been implicated as potential etiologies of drug-induced LABD (Table II).5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
We report a 65-year-old man with sepsis and renal failure, who developed LABD 14 days after receiving his last dose of vancomycin. Of 8 reported cases, all but
References (38)
- et al.
Chronic bullous disease of childhood, childhood cicatricial pemphigoid, and linear IgA disease of adults: a comparative study demonstrating clinical and immunopathologic overalp
J Am Acad Dermatol
(1988) - et al.
Vancomycin-induced linear IgA bullous dermatosis (LABD)
J Am Acad Dermatol
(1996) - et al.
Drug-induced linear IgA bullous dermatosis: report of six cases and review of the literature
J Am Acad Dermatol
(1994) - et al.
Phenytoin-induced linear IgA bullous disease
J Am Acad Dermatol
(1998) - et al.
Vancomycin associated linear IgA dermatosis
J Am Acad Dermatol
(1992) - et al.
Amiodarone-induced linear IgA disease
J Am Acad Dermatol
(1994) - et al.
Linear IgA bullous dermatosis after heart transplantation
J Am Acad Dermatol
(1990) - et al.
Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120-KDa keratinocyte collagenous glycoprotein with cross-reactivity to BP 186
J Invest Dermatol
(1997) - et al.
The 97-Kda linear IgA bullous disease antigen is identical to a portion of the extra-cellular domain of the 180-Kda bullous pemphigoid antigen, BPAg2
J Invest Dermatol
(1998) - et al.
Linear IgA disease in adults
Br J Dermatol
(1982)
Linear IgA bullous dermatosis: an immunologically defined disease
Int J Dermatol
Histology of linear IgA disease, dermatitis herpetiformis, and bullous pemphigoid
Am J Dermatopathol
Vancomycin-induced linear IgA bullous dermatosis
Arch Dermatol
A bullous eruption in an elderly woman: vancomycin-associated linear IgA dermatosis
Arch Dermatol
Linear IgA dermatosis related to vancomycin
Br J Dermatol
Purpura with a linear epidermodermal deposition of IgA
Acta Derm Venereol (Stockh)
Dermatose bulleuse á IgA linéaire au décours immédoat d’une urographie intra-veineuse
Arch Dermatol Venereol
Dermatose á IgA linéaire induite par la pénicilline G
Ann Dermatol Venereol
Dermatoses bulleuses á IgA linéaire
Cited by (0)
- ☆
This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology.
- ☆☆
Reprints requests: Jeffrey P. Callen, MD, 310 E Broadway, #200, Louisville, KY 40202.
- ★
0190-9622/2000/$12.00 + 0 16/4/96948