Copyright © 2003 Elsevier B.V. All rights reserved.
Quest for a sensible null distribution in longitudinal microarray experiments
Received 29 January 2003;
References and further reading may be available for this article. To view references and further reading you must purchase this article.
Abstract
Clustering methods and “heat maps” are frequently used in DNA microarray analysis. Sometimes, the association of longitudinal observation vectors is demonstrated by a side-to-side comparison with a heat map generated from an assumed null distribution, which is generated by permuting the points in time. A certain amount of structure can be attributed to the smoothness of biological processes in time without assuming association between different vectors. A polynomial regression for the data and the clustering of genes in the space of parameter estimates is suggested. Applying the group finding rule in the reduced space provides slightly more stable clusters which preserve some similarity with the original ordering.
Author Keywords: Cluster analysis; Exploratory data analysis; DNA-microarrays






E-mail Article
Add to my Quick Links

Cited By in Scopus (0)






