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Computational Statistics & Data Analysis
Volume 44, Issues 1-2, 28 October 2003, Pages 339-347
Special Issue in Honour of Stan Azen: a Birthday Celebration
 
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doi:10.1016/S0167-9473(03)00065-3    How to Cite or Link Using DOI (Opens New Window)
Copyright © 2003 Elsevier B.V. All rights reserved.

Quest for a sensible null distribution in longitudinal microarray experiments

Johannes HüsingCorresponding Author Contact Information, E-mail The Corresponding Author, Irina Gana DresenE-mail The Corresponding Author and Karl-Heinz JöckelE-mail The Corresponding Author

Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universität Duisburg-Essen, Hufelandstrae 55, D45122, Essen, Germany

Received 29 January 2003; 
accepted 19 March 2003. ;
Available online 25 April 2003.

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Abstract

Clustering methods and “heat maps” are frequently used in DNA microarray analysis. Sometimes, the association of longitudinal observation vectors is demonstrated by a side-to-side comparison with a heat map generated from an assumed null distribution, which is generated by permuting the points in time. A certain amount of structure can be attributed to the smoothness of biological processes in time without assuming association between different vectors. A polynomial regression for the data and the clustering of genes in the space of parameter estimates is suggested. Applying the group finding rule in the reduced space provides slightly more stable clusters which preserve some similarity with the original ordering.

Author Keywords: Cluster analysis; Exploratory data analysis; DNA-microarrays

Article Outline

1. Introduction
2. Parametrizing the time-dependent data
3. Simulated data
4. Class detection after parametrization
5. Discussion
References






Computational Statistics & Data Analysis
Volume 44, Issues 1-2, 28 October 2003, Pages 339-347
Special Issue in Honour of Stan Azen: a Birthday Celebration
 
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