ReviewIL-10, an inflammatory/inhibitory cytokine, but not always
Section snippets
IL-10 and mast cells
Activated mast cells through their high affinity IgE receptors (FcεRI) produce diverse preformed granule mediators, such as histamine and proteinases as well as a wide variety of pro-inflammatory cytokines (Fig. 3) [26], [27], [28]. IL-10 alone fails to support the growth of mast cell lines and mast cell progenitors [29], but significantly enhances the growth activity of stem cell factor (SCF) [30]. IL-10 in combination with other cytokines is optimal for mast cell development from cord blood
Acknowledgements
The authors are indebted to Neopharmed, an Italian entity of Merck & Co., Withehouse Station, NJ, USA for their financial support.
References (48)
- et al.
J. Biol. Chem.
(1995) - et al.
J. Biol. Chem.
(1996) - et al.
Blood
(1997) - et al.
Immunol. Lett.
(1997) - et al.
Ann. Rev. Immunol.
(1989) - et al.
Ann. Rev. Immunol.
(2001) - et al.
Int. Arch. Allergy Immunol.
(1992) - et al.
J. Immunol.
(2002) - et al.
J. Immunol.
(2002) - et al.
Oncogene
(2000)
Science
Int. J. Immunopathol. Pharmacol.
Int. J. Immunopathol. Pharmacol.
Int. J. Immunopathol. Pharmacol.
J. Immunol.
J. Immunol.
J. Immunol.
J. Clin. Invest.
Int. J. Immunopathol. Pharmacol.
J. Immunol.
J. Immunol.
J. Exp. Med.
J. Immunol.
J. Immunol.
Cited by (195)
NK cell therapy in relapsed refractory multiple myeloma
2023, Clinical ImmunologyMultifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair
2023, Acta BiomaterialiaCitation Excerpt :To improve the inflammatory regulation effects, interleukin (IL)-10 was added to the gelatin-based hydrogel [18]. IL-10 is an inflammatory and immunosuppressive factor that plays a role in infection, inflammation, and organ transplantation [19,20]. It is mainly produced by T helper 2 (Th2) cells, macrophages, and CD8+ cell clones.
Emerging role of natural products in cancer immunotherapy
2022, Acta Pharmaceutica Sinica B