Outcomes of Trabeculectomy for Primary Open-angle Glaucoma*
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2018, Advances in Ophthalmology and OptometryCitation Excerpt :In addition, with time, perhaps because of multiple limited instances of inflammation, the scarring process continues, eventually resulting in limitation to flow and higher intraocular pressures. Late failure to control intraocular pressure can occur in 50% [4] or more of patients following glaucoma filtration surgery [4,5]. To address the rate of initial failure, multiple approaches have been made.
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2018, Protein Expression and PurificationCitation Excerpt :This high IOP many not be lowered sufficiently by current IOP-lowering medications thus, requiring these patients to have IOP-lowering surgery. IOP-lowering surgeries are prone to failure [19], so these young patients will require numerous such surgeries during their lifetime. Despite intensive research efforts, the function of wild-type (wt) MYOC remains unknown and how mutant MYOC contributes to glaucoma disease pathology is ambiguous [20,21].
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Presented at the American Academy of Ophthalmology Annual Meeting, San Francisco, November 1994.