Elsevier

Ophthalmology

Volume 98, Issue 6, June 1991, Pages 957-962
Ophthalmology

Delayed Rod Dark Adaptation in Patients with Stargardt's Disease

https://doi.org/10.1016/S0161-6420(91)32196-1Get rights and content

Abstract

Twelve patients with Stargardt's dystrophy were each found to have a prolongation in rod dark adaptation. All had a normal rate of recovery during the early portion of rod dark adaptation but a selective prolongation of the later segment of rod recovery. This observation was apparent in patients with limited fundus flecks and those with extensive fundus flecks, whether or not a dark choroid was observed and independent of the presence or absence of an atrophic-appearing macular lesion. A defect within retinal pigment epithelial cells of an enzyme or intracellular transport mechanism involved in the visual pigment regeneration cycle could account for these findings.

References (32)

  • A Franceschetti

    A special form of tapetoretinal degeneration: fundus flavimaculatus

    Trans Am Acad Ophthalmol Otolaryngol

    (1965)
  • AE Krill et al.

    Flecked retina syndrome

    Arch Ophthalmol

    (1965)
  • A Franceschetti et al.

    Fundus flavimaculatus

    Arch Ophtalmol (Paris)

    (1965)
  • AE Krill

    ERG in fundus flavimaculatus

    Jpn J Ophthalmol

    (1966)
  • A Tamai et al.

    Three cases of fundus flavimaculatus

    Yonago Acta Med

    (1970)
  • AF Deutman
  • Cited by (0)

    Supported by core grant EY01792 and research grant EY08301 from the National Eye Institute, National Institutes of Health, Bethesda, Maryland, and by a center grant from the National RP Foundation Fighting Blindness, Baltimore, Maryland.

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