Direct evidence that γ1 and γ3 switching in human B cells is interleukin-10 dependent
References (48)
- et al.
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Anal. Biochem.
(1987) - et al.
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-LoxP-mediated gene targeting
Cell
(1993) - et al.
Biological properties of interleukin 10
Immun. Today
(1992) - et al.
Circular DNA is excised by immunoglobulin class switch recombination
Cell
(1990) - et al.
Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switch
Cell
(1990) - et al.
Single step separation of human T and B cells using AET treated SRBC rosettes
J. Immun. Meth.
(1976) - et al.
Structure of chi hotspots of generalized recombination
Cell
(1981) - et al.
Nuclear proteins binding to a novel target sequences within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family
Oncogene
(1994) - et al.
Human B cell proliferation and Ig secretion induced by recombination CD40 ligand are modulated by soluble cytokines
J. Immun.
(1993) - et al.
Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3
J. Exp. Med.
(1994)
A common sequence motif near nonhomologous recombination breakpoints involving Ig sequences
J. Immun.
Inteleukin-10 and transforming growth factor B cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A
J. Exp. Med.
B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10
J. Immun.
Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε, and α genes
Nature
Swainsonine augments the cytotoxicity of human lymphokine-activated killer cells against autologous thyroid cancer cells
Arch. Otolaryngol. Head Neck Surg.
IL-4 plus CD40 monoclonal antibody induces human B cells g subclass specific isotype switching: Switching to γ1, γ3 and γ4, but not γ2
J. Immun.
Vasoactive intestinal peptide induces switch circular DNA in human B cells
J. Clin. Invest.
Multiple types of chimeric germ-line immunoglobulin heavy chain transcripts in human B cells: Evidence for trans-splicing of human immunoglobulin RNA
J. Immun.
Sequence complexity of circular Epstein-Barr virus DNA in transformed cells
J. Virol.
Organization of immunoglobulin heavy chain genes and allelic deletion model
Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1
Science
Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolysaccharide
J. Exp. Med.
Sequential switching from μ to ε via γ4 in human B cells stimulated with IL-4 and hydrocortisone
J. Immun.
Shutdown of class switch recombination by deletion of a switch region control element
Science
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IgE antibodies against Trypanosoma cruzi arginine kinase in patients with chronic Chagas disease
2021, Molecular ImmunologyCitation Excerpt :IgG subclasses can also be linked to the Th1/Th2 cytokine balance, with IgG1 and IgG3 being related to a predominantly Th1 response, while Th2 is associated with IgG4 (Holdsworth et al., 1999). IL-4 can stimulate the switch of B cells directly to γ-4 (Jabara et al., 1993), while switch from μ to γ-1 and γ-3 is dependent on IL-10 (Fujieda et al., 1996). In that sense, our results showed the presence of IgG4 but not IgG1 and IgG3 against TcAK, reinforcing the idea of the protein leaning the immune response towards Th2, and that the switch to IgE might be occurring straightly from μ to γ-4, not passing through γ-3, γ-1 and γ-2.
Class Switch Recombination: A Comparison Between Mouse and Human
2007, Advances in ImmunologyCitation Excerpt :Thus far, no human IgG‐subclass‐specific “switch factor” has been described. In the presence of anti‐CD40 antibodies, IL‐4 can induce CSR to IgG1, IgG3, and IgG4 (Armitage et al., 1993; Fujieda et al., 1995), whereas IL‐10 induces CSR to IgG1 and IgG3 (Briere et al., 1994; Fujieda et al., 1996). IL‐10 is not a switch factor for IgG4, but addition of IL‐10 augments IL‐4‐induced γ4 expression and IgG4 production (Jeannin et al., 1998).
Absence of immunoglobulin class switch in primary lymphomas of the central nervous system
2005, American Journal of PathologyCitation Excerpt :For example, GC B cells in Peyer's patches of the small intestine preferentially switch to IgA, whereas GC B cells in lymph nodes usually switch to IgG. In this regard, the regional cytokine milieu, in particular interleukin (IL)-4, IL-10, and transforming growth factor-β, may play a critical role in controlling CSR.20–23 Under physiological conditions in the CNS, only low levels of cytokines such as IL-10, but no IL-4, can be detected.24
Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells
2005, BloodCitation Excerpt :Murine B cells undergo immunoglobulin class switch to IgG1 in response to stimulation by IL-4.41 In human cells, this cytokine induces class switch to IgG4 and IgE,42,43 whereas several factors seem to be able to induce class switch of human B cells to IgG1 in vitro.44,45 During Lyme borreliosis infection, a pathogen inducing a strong IFN-γ response, IgG1, together with IgG3, is the dominant immunoglobulin isotype.46
Analysis of IGG and IGG4 in HIV-1 seropositive patients and correlation with biological and genetic markers
2005, Biomedicine and PharmacotherapyCitation Excerpt :After an antigenic stimulation, the naïve B cells can undergo isotype switching to produce IgG, IgA, or IgE antibodies. Through the production of various cytokines [1–4], T cells can control the progress of Ig isotype switching by providing signals to the B cells: IL10 promotes the isotype switching to IgG1 and IgG3 [5,6], and IL4 and IL13 to IgG4 and IgE [7–9]. As expected, the production of antibodies is higher in HIV-1 infected patients than in healthy individuals [10].