Lipid peroxidation-coupled co-oxygenation of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol in human term placental microsomes
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Cited by (12)
Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts
2023, Ecotoxicology and Environmental SafetyThe impact of Triton WR-1339 induced hyperlipidemia on the effects of benzo(a)pyrene or guaiacol on α- and γ-tocopherol pools and selected markers of pro-/antioxidative balance in rat plasma and erythrocytes
2012, Environmental Toxicology and PharmacologyCitation Excerpt :The quinones redox-cycle is a well-known source of free radicals, including semiquinone radical anions and superoxide radical anions (Ternay and Sorokin, 1997; Song and Buettner, 2010). One-electron activation of BaP may be mediated by enzymes or may be the result of co-oxygenation in the process of lipid peroxidation (Byczkowski and Kulkarni, 1990b). Recently, Alexandrov et al. (2006, 2010) have pointed out that lipid peroxyl radicals, formed during lipid peroxidation process, can activate BaP in cigarette smokers, Thus, under conditions conducive to increased lipid peroxidation, one can expect severe pro-oxidative effects of BaP.
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