Elsevier

The Lancet

Volume 353, Issue 9165, 15 May 1999, Page 1680
The Lancet

Research Letters
From effect size into number needed to treat

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    In addition, we calculated the prediction interval, which indicates the range in which the true effect size of 95% of all populations will fall. Numbers-needed-to-be-treated (NNT) were calculated using the formula provided by Furukawa (1999), in which the event rate of the control group was set conservatively at 19% (based on the pooled response rate of 50% reduction of symptoms across trials in psychotherapy for depression) (Cuijpers, et al., 2014). We tested for publication bias by inspecting the funnel plot on primary outcome measures and by Duval and Tweedie's trim and fill procedure (Duval & Tweedie, 2000) as implemented in CMA, which yields an estimate of the effect size after the publication bias has been taken into account.

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