Elsevier

The Lancet

Volume 344, Issue 8922, 27 August 1994, Pages 583-584
The Lancet

Short reports
Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer

https://doi.org/10.1016/S0140-6736(94)91968-2Get rights and content

Abstract

Urokinase-type plasminogen activator (u-PA) is a serine protease involved in cancer metastasis. Using immunohistochemical methods, we examined the relation between u-PA and long-term survival in 70 patients with Dukes' B colorectal cancer. 8-year survival was 81% in patients whose tumours demonstrated low-grade epithelial u-PA staining and 43% in those with high-grade staining (log-rank test, p=0·01). Survival was unrelated to stromal u-PA staining. These results suggest that u-PA may be useful in the identification of patients with non-metastatic colorectal cancer at risk of tumour recurrence.

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